Nomogram for predicting invasion in patients with a preoperative diagnosis of ductal carcinoma in situ of the breast

摘要: Background The aim of this study was to identify risk factors for invasive breast cancer in patients diagnosed with ductal carcinoma situ (DCIS) on a preoperative biopsy. These were used develop nomogram predicting the invasion setting. Methods This retrospective analysis who underwent surgical treatment DCIS before surgery between 1997 and 2009. Multivariable clinical, radiological histopathological that may predict upstaging. A developed probability using multiple logistic regression analysis. This subsequently validated another cohort diagnosis 2010 2012. Results Upstaging occurred 123 (24.9 per cent) 493 women treated larger lesion (at least 15 mm), lack hormone receptor expression, intermediate or high nuclear grade, core biopsy compared vacuum-assisted biopsy, non-cribriform subtype significantly associated these demonstrated good predictive performance (area under receiver operating characteristic (ROC) curve (AUC) 0·823, 95 cent confidence interval 0·787 0·860). The showed similar validation data set, based 149 (AUC 0·700, 0·613 0·786). Conclusion Upstaging is common. five most significant related upstaging accurately predicted cancer. be useful when deciding whether pursue axillary staging sentinel lymph node DCIS.