Molecular components of vertebrate Mg2+-homeostasis regulation.

摘要: Over the past decades, clinical relevance and biological significance of Mg 2+ have been thoroughly documented. Although multiple 2+-transport pathways biophysically characterized, molecular identity postulated components 2+-homeostasis regulation in vertebrates remain undefined. Recent advances fields genetics, genomics proteomics, novel technologies such as cDNA microarrays allowed for substantial progress this area. The mitochondrial Mrs2 protein was first human transporter characterized such, an important element future analyses role mitochondria managing intracellular 2+. Several molecules with capabilities identified through a screen designed to find genes upregulated under hypomagnesic conditions. This includes SLC41A1 2, ACDP2 MagT1. Finally, elucidation cause underlying two different hereditary diseases leading hypomagnesemia resulted cloning characterization claudin 16 (paracellin-1), TRPM6. Whereas plays crucial paracellular transport, TRPM6 is involved transcellular pathway. its closest relative TRPM7 are both puzzling ion channel-kinase fusions, perhaps most unexpected newly players vertebrates.