Is incidental prophylactic oophorectomy an acceptable means to reduce the incidence of ovarian cancer

摘要: Background According to previous reports, the lifetime risk of developing ovarian carcinoma is 1.4%. This figure varies with age from 6.6 per 100,000 among women aged 35 39 years up 55.1 75 79 years. Prophylactic oophorectomy remains a modality decrease incidence cancer. What proportion diagnosed an malignancy had preceding laparotomy at which time prophylactic could have been performed? Methods We reviewed new cancer diagnoses seen in patients between August 1988 and 1993 Ottawa Regional Cancer Foundation. Four hundred four were identified. These analyzed for abdominal surgery, age, disease progression, death, death other causes, average follow-up. The surgeries divided into: (1) major gynecological surgery;and (2) general surgery procedures, further into pelvic (group A surgeries) that included (ie, appendectomy, cholecystectomy) where access pelvis be more difficult B surgeries). Results total 270 was performed, prior diagnosis group stratified according timing (≤40 years, 41 45 46 50 >50 years). Based on these data, grouping gynecologic plus surgical procedures A, 10.9% cancers would prevented if performed who over 40 age;over this 6.7%, it 4%. If one adds all surgeries, including groups B, results 26.9% 20% 45, 16.6% 50. Conclusion found that, depending patient, 4% reduction carcinoma. increases considers difficult. Although we are not advocating frequent use procedure, recommend surgeons routinely discuss option before their postmenopausal female 49 age. Given decision multifaceted, feel scoring discussion benefit ratio should undertaken. ultimate goal heighten patient awareness factors ensure informed made concerning consistently lethal disease.