作者: J.M. Kaguni
DOI: 10.1016/B978-0-12-378630-2.00313-3
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摘要: In free-living organisms, including Escherichia coli , DNA replication starts at origins. E. contains a single origin ( oriC ), which serves as the site for assembly of replisome, multi-protein molecular machine that duplicates circular duplex genome. Replisome is highly regulated event strictly coordinated with cell cycle. This article reviews mechanism replisome origin.