On Helicases and other motor proteins
作者： Eric J Enemark , Leemor Joshua-Tor
DOI: 10.1016/J.SBI.2008.01.007
关键词: DNA 、 Helicase 、 Nucleic acid 、 Motor protein 、 Biochemistry 、 Nucleotide 、 RNA Helicase A 、 ATP hydrolysis 、 Biology 、 Binding site
摘要: Helicases are molecular machines that utilize energy derived from ATP hydrolysis to move along nucleic acids and separate base-paired nucleotides. The movement of the helicase can also be described as a stationary pumps acid. Recent structural data for hexameric E1 papillomavirus in complex with single-stranded DNA MgADP has provided detailed atomic mechanistic picture its ATP-driven translocation. features this compared prototypes T7gp4 SV40 T-antigen. ATP-binding site architectures these proteins structurally similar sites other prototypical motors such F1-ATPase, suggesting related roles individual residues ATPase activity.
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