Lipid peroxidation in patients with schizophrenia.

摘要: Aims:  There is evidence that dysregulation of free radicals metabolism associated with abnormal activities antioxidative enzymes in schizophrenia can lead to lipid peroxidation plasma, erythrocytes, blood platelets and cerebrospinal fluid. Injury neurons may affect their function, i.e. membrane transport, impairment energy production mitochondria, changes phospholipid composition, alteration receptors transporters as well neurotransmission. The purpose the present study was assess total antioxidant capacity (TAC) (expressed level thiobarbituric acid reactive substances [TBARS]) plasma from schizophrenic patients taking olanzapine or risperidone. TBARS estimated according Rice–Evans method TAC ([ABTS; 2,2′-azinobis-(3-ethylbenzothiazoline-6-sulfonic acid) radical cation decolorization assay]) (DSM-IV criteria for schizophrenia, n = 30, age 18–36) risperidone healthy volunteers (n = 30) were measured. Methods:  after incubation also estimated. Results:  Significantly lower (P   0.05). obtained results indicate pro-oxidant disturbances occur (acute episode) stable doses risperidone. Conclusion:  It seems second-generation antipsychotics (olanzapine risperidone) are not responsible increase peroxidation.