Role of nitric oxide and related molecules in schizophrenia pathogenesis: biochemical, genetic and clinical aspects.

摘要: Currently, schizophrenia is considered a multifactorial disease. Over the past 50 years, many investigators have role of toxic free radicals in etiology schizophrenia. This an area active research which still evolving. Here, we review recent data and current concepts on roles nitric oxide (NO) related molecules pathogenesis NO involved storage, uptake release mediators neurotransmitters, including glutamate, acetylcholine, noradrenaline, GABA, taurine glycine. In addition, diffuses across cell membranes activates its own extrasynaptic receptors. Further, peroxidation reactive oxidative stress. Investigations reveal significant disturbances levels brain structures (cerebellum, hypothalamus, hippocampus, striatum) fluids subjects with Given central nervous system development, these changes may result neurodevelopmental associated We describe here literature NOS gene polymorphisms schizophrenia, all point to consistent results. also discuss how be new target for therapy mental disorders. Currently there been 2 randomized double-blind placebo-controlled trials L-lysine as inhibitor CNS.