Efficacy and tolerability of minocycline augmentation therapy in schizophrenia: a systematic review and meta-analysis of randomized controlled trials.
作者： Kazuto Oya , Taro Kishi , Nakao Iwata , None
DOI: 10.1002/HUP.2426
关键词:
摘要: Objective This study aimed to perform a comprehensive meta-analysis of minocycline augmentation therapy in patients with schizophrenia receiving antipsychotic agents. Methods Data published up 2 June 2014 were obtained from the PubMed, PsycINFO, Google Scholar, and Cochrane Library databases. We conducted systematic review patient data randomized controlled trials (RCTs) comparing placebo. Relative risk (RR), standardized mean difference (SMD), 95% confidence intervals calculated. Results We included four RCTs. The total sample 330 patients. Minocycline was superior placebo for decreasing Positive Negative Syndrome Scale (PANSS) scores (SMD = −0.70), PANSS negative subscale (SMD = −0.86), general (SMD = −0.50) but not different positive (SMD = −0.26) depressive symptoms (SMD = −0.28). equivalent all-cause discontinuation (RR = 1.10), due inefficacy (RR = 0.42), adverse events (RR = 1.56), death (RR = 3.18). extrapyramidal side-effect (SMD = −0.32). Conclusions Minocycline may improve psychopathology schizophrenia, especially symptoms, seems be well tolerated. Copyright © John Wiley & Sons, Ltd.
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