HTLV-1-mediated immunopathological CNS disease.

摘要: Human T-lymphotropic virus 1 (HTLY-1) was the first known human retrovirus. It discovered in a patient with cutaneous T cell lymphoma (Poiesz et al. 1980; Reitz 1981). A little later, Japanese and American researchers established that this retrovirus cause of adult lymphoma/leukemia (ATL), characteristic recognized Japan years before (Uchiyama 1977). Nervous system involvement had been shown murine leukemia (MLV; Pal 1983) immunodeficiency (HIV) infections (Snider 1983). Therefore several research groups investigated short succession patients chronic progressing myelopathies, called tropical spastic paraparesis (TSP) countries, for antiretroviral antibodies (Gessain 1985; Rodgers-Johnson Osame 1986). They clearly majority serum to HTLV-1. Subsequently, new disease entity defined HTLV-1 associated myelopathy/tropical (HAM/TSP; 1990).