Differential Effects of Apolipoprotein A-I–Mimetic Peptide on Evolving and Established Atherosclerosis in Apolipoprotein E-Null Mice
作者： Xiaojun Li , Kuang-Yuh Chyu , Jose R. Faria Neto , Juliana Yano , Nitya Nathwani
DOI: 10.1161/01.CIR.0000142857.79401.69
关键词:
摘要: Background— Apolipoprotein (apo) A-I and apoA-I–mimetic peptides showed promise to prevent atherosclerosis development. Using a bypassed vein graft model in apoE-null mice, we evaluated the effects of oral or intraperitoneal administration an peptide on evolving atherosclerotic lesions compared such established aortic sinus same mice. Methods Results— We used mice which segment inferior vena cava was grafted into right carotid artery at 16 weeks age. Native (established atherosclerosis) vein-graft (evolving were assessed 4 after daily (0.3 mg/mL) (50 μg 200 μL saline) peptide, D4F. Mice receiving saline water without D4F served as controls. Both reduced lesions)...
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