Dopamine D3 and D4 receptor antagonists in the treatment of schizophrenia.

摘要: The findings that dopamine D3 and D4 receptors are highly expressed in limbic cortical areas (D4 more than D3), the fact atypical drug clozapine has preferential affinity for have suggested an involvement of these schizophrenia. Subsequently, many pharmaceutical companies pursued approach developing selective or antagonists as potential antipsychotics. This review will discuss current status receptor treatment