Exercise offers anxiolytic potential: A role for stress and brain noradrenergic-galaninergic mechanisms

摘要: Although physical activity reduces anxiety in humans, the neural basis for this response is unclear. Rodent models are essential to understand mechanisms that underlie benefits of exercise. However, it controversial whether exercise exerts anxiolytic-like potential rodents. Evidence reviewed evaluate effects wheel running, an experimental mode rodents, on behavior tests and norepinephrine galanin systems circuits regulate stress. Stress proposed account mixed behavioral findings literature. Indeed, running promotes adaptive stress alters anxiety-like behaviors a manner dependent Running amplifies expression noradrenergic locus coeruleus (LC) suppresses stress-induced LC output LC-target regions. Thus, enhanced galanin-mediated suppression brain runners supported by current literature as mechanism may contribute stress-protective These data support use rodents study emotional neurobiological consequences