Abnormalities of the APC/β-catenin pathway in endometrial cancer

摘要: The activation of the APC/β-catenin signalling pathway due to β-catenin mutations has been implicated in development a subset endometrial carcinomas (ECs). However, up 25% ECs have nuclear accumulation without evidence mutations, suggesting alterations other molecules that can modulate Wnt pathway, such as APC, γ-catenin, AXIN1 and AXIN2. We investigated expression pattern β- γ-catenin group 128 carcinomas, including 95 endometrioid (EECs) 33 non-endometrioid (NEECs). In addition, we evaluated presence loss heterozygosity promoter hypermethylation APC gene AXIN1, AXIN2, RAS genes, phospho-Akt expression. No were detected but LOH at locus was found 24.3% informative cases. 1A observed 46.6% ECs, associated with phenotype (P=0.034) microsatellite instability (P=0.008). Neither nor catenin Nuclear 31.2% EECs 3% NEECs (P=0.002), significantly exon 3 (P<0.0001). phenotype, 14 (14.9%) EECs, none (P=0.02). 10 ECs; it not histological type more advanced stages (P=0.042). 2 genes this series. expression, which 16 27.6% cases, respectively, Our results demonstrated high prevalence only are aberrant localization β-catenin.