Single-molecule kinetics with time-dependent rates: a generating function approach.
作者： Frank L. H. Brown
DOI: 10.1103/PHYSREVLETT.90.028302
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摘要: A theoretical strategy for calculating the statistical properties of time series generated by single molecule measurements is presented. Emphasis placed on case where observable states interconvert via rate ``constants'' exhibiting stochastic dependence. Such fluorophores coupled to biomolecules undergoing conformational fluctuations [H. P. Lu, L. Xun, and X. S. Xie, Science 282, 1877 (1998)]. In contrast previous studies, we focus number fluorophore blinking events occurring within a given amount as our variable. This formulation allows an elementary analysis generating function framework.
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