Protective effect of diallyl sulfide on oxidative stress and nephrotoxicity induced by gentamicin in rats.

摘要: Gentamicin (GM) is an antibiotic whose clinical use limited by its nephrotoxicity. Experimental evidences suggest a role of reactive oxygen species in GM-induced In this work we explored the effect diallyl sulfide (DAS), garlic-derived compound with antioxidant properties, on Four groups rats were studied: (1) Control, treated intragastrically olive oil as vehicle, (2) GM, subcutaneously GM (125 mg/kg/day for 4 days), (3) DAS, DAS (50 and (4) + DAS. Nephrotoxicity was made evident by: increase creatinine blood urea nitrogen serum, urinary excretion N-acetyl-β-D-glucosaminidase total protein, necrosis proximal tubular cells. These functional structural alterations prevented or ameliorated treatment. addition, increased levels renal oxidative stress markers nitrotyrosine protein carbonyl which also group. The mechanism has protective nephrotoxicity may be related, at least part, to decrease cortex.