T lymphocyte activation by staphylococcal enterotoxins: Role of class II molecules and T cell surface structures

摘要: Abstract The enterotoxins produced by Staphylococcus aureus (SE) are the most potent mitogens known. Triggering of proliferation or cytotoxicity SE requires presence MHC class II molecules on accessory target cells. In this study we have investigated role HLA in activation human T cells and nature structure responding lymphocyte for SE. This dependence is not due to an immunological “recognition” since there no restriction polymorphic determinants even xenogeneic can reconstitute cell response Furthermore, II-positive but -negative absorb mitogenic activity from solutions significant binding 125 I-labeled be demonstrated II-negative Enterotoxin react directly with they cause increase cytosolic Ca 2+ concentration similar anti-CD3 mAb. abrogated prior modulation TCR/CD3 complex. Antibodies CD2, CD3 TCR that block antigen-specific also Moreover, preincubation purified resting cell-free leads Taken together these data indicate interact selectively a TCR-associated cell.