Enantioselective Michael Addition of Malonates to Chalcone Derivatives Catalyzed by Dipeptide-derived Multifunctional Phosphonium Salts
作者： Dongdong Cao , Guosheng Fang , Jiaxing Zhang , Hongyu Wang , Changwu Zheng
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摘要: Highly enantioselective Michael addition of malonates to enones catalyzed by dipeptide-derived multifunctional phosphonium salts has been developed. The newly established catalytic system was characterized with its wide substrate scope featured aliphatic aldehyde-derived and substituted malonates. gram scale-up synthesis adducts can also be successfully achieved under optimal conditions both excellent yield enantioselectivity.
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