The in vitro transmission frequency of the t12 mutation in the mouse

摘要: Male mice which are heterozygous for a recessive lethal mutation (+ / t L ) transmit the in non-Mendelian ratios. In present studies, spermatozoa obtained from + 12 males were used to fertilize ova females vitro . The frequency of transmission determined these studies was compared with this normal and delayed matings. data show that mutation, , is Mendelian same as vivo when matings until time ovulation.