Low Frequency of Mouse t Haplotypes in Wild Populations Is Not Explained by Modifiers of Meiotic Drive

摘要: t haplotypes are naturally occurring forms of mouse chromosome 17 that show non-Mendelian transmission from heterozygous +/t males. In laboratory studies, ratios >=0.90 or higher typically observed. With this level, theoretical analyses predict high frequencies (~ 75%) in wild populations. contrast, empirical only 15-25% found. This has led to the suggestion modifiers drive may play a role reducing frequencies. We have measured ratio distortion (TRD) levels mice examine hypothesis. TRD was very both litters collected wild-caught pregnant females, and bred (mean = 0.9). Contrary results other we found no difference between semilethal lethal nor conceived cycling postpartum estrus. three with aberrantly low TRDs were all multiply sired, although might natural populations is unknown. These findings general absence suggest factors responsible for observed haplotypes.