Effect of a phase I Coxiella burnetii inactivated vaccine on body temperature and milk yield in dairy cows

摘要: Q fever is a zoonotic disease caused by Coxiella burnetii. The pathogen prevalent in ruminants (goats, sheep, cows), which are the main sources of human infection. In cattle industry around world, animal (15 to 20%) and herd (38 72%) level prevalences C. burnetii high. Vaccination against considered important prevent spreading risk infection humans. However, published information on side effects vaccination under field conditions limited for cows. objective this study was investigate effect phase I inactivated vaccine Coxevac body temperature milk yield dairy 2 experiments, total 508 cows were randomly divided into groups determine first yield. serostatus all tested before with an indirect ELISA. experiment took place teaching research barn Clinic Animal Reproduction at Freie Universitat Berlin. Temperature measured vaginally 10 crossover design. second conducted commercial farm. Milk 498 1 wk after vaccination. subset 41 cows, rectally. both increased significantly (1.0 ± 0.9°C 0.7 0.8°C). A significant difference also found between vaccinated control Thirty percent animals showed reversible swelling injection site as reaction results indicate that causes transient increase peaks 12 24h declines that. 2, (26.8 0.39 kg/d) produced less than did (28.2 0.44 7d cumulative loss influenced interaction average This part physiological immune response. Three out painful skin site, had maximum size 14.0 × 1.1cm. conclusion, decrease