Phototriggerable peptidomimetics for the inhibition of Mycobacterium tuberculosis ribonucleotide reductase by targeting protein–protein binding

摘要: Incorporation of an artificial amino acid 2 with a stilbene chromophore into peptidomimetics three to nine acids yields phototriggerable candidates for inhibition the binding between R1 and R2 subunits M. tuberculosis ribonucleotide reductase (RNR). Interstrand hydrogen bond probability was used as guideline predicting conformational preferences photoisomers. Binding these inhibitors has been rationalized by docking studies unit. Significant differences in photoisomers were observed. For shorter peptidomimetics, stronger Z isomer might indicate hydrophobic interactions site.