Glycan regulation of ER-associated degradation through compartmentalization.

摘要: The internal environment of the eukaryotic cell is divided by membranes into various organelles, containing diverse functional subcompartments, which allow complex cellular life. quality control newly made secretory proteins relies on ability endoplasmic reticulum (ER) to segregate and compartmentalize molecules at different folding states. These states are communicated N-glycans present most proteins. In ER-associated degradation (ERAD), protein that have been identified as terminally misfolded sent for cytosolic proteasomes after being dislocated from ER cytosol. This review will focus how glycoprotein segregated their properly folded counterparts targeted ERAD. pathway involves compartmentalization, intimately linked differential N-glycan processing. Recent data suggests these processes very dynamic, include transient assembly ERAD machinery complexes.