IgE and IgG cross-reactivity among Lol p I and Lol p II/III.
作者： R. Ree , W. A. Leeuwen , M. Berg , H. H. Weller , R. C. Aalberse
DOI: 10.1111/J.1398-9995.1994.TB02658.X
关键词:
摘要: In this study, the homologous C-termini of Lol p I, II, and III were shown to contain cross-reactive B-cell epitopes. This was demonstrated by inhibition studies with purified synthetic peptides their C-termini. It ruled out that observed cross-reactivity caused cross-contamination allergens. Both human IgE IgG bound C-terminus I. These antibodies II and, more specifically, its C-terminus. Within a small panel allergic patients, no found. A hyperimmune polyclonal rabbit antiserum against I also recognized As for antibodies, demonstrated. Cross-reactivity C-terminal peptides, but not native III. both binding inhibited confirming structures exist only on The existence between possibly contributes frequently cosensitization these allergens in grass-pollen-allergic patients.
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