Nucleoside analogue delivery systems in cancer therapy
作者： Roudayna Diab , Ghania Degobert , Misara Hamoudeh , Charles Dumontet , Hatem Fessi
关键词:
摘要: Nucleoside analogues (NAs) are important agents in the treatment of hematological malignancies. They prodrugs that require activation by phosphorylation. Their rapid catabolism, cell resistance and overdistribution body jeopardize nucleoside analogue chemotherapy. Accordingly, therapeutic doses NAs particularly high regularly have to be increased, resulting severe toxicity narrow index. The major challenge is concentrate drug at tumour site, avoiding its distribution normal tissues. New carriers biomaterials being developed overcome some these obstacles. This review highlights novel NA delivery systems discusses new technologies could improve cancer therapy.
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