Haemophilus influenzae type b and cross-reactive antigens in natural Hib infection dynamics; modelling in two populations
作者： T. LEINO , K. AURANEN , P. H. MÄKELÄ , H. KÄYHTY , M. RAMSAY
DOI: 10.1017/S0950268802007173
关键词:
摘要: Natural immunity to Haemophilus influenzae type b (Hib) invasive disease is based on antibodies arising in response encounters with Hib or cross-reactive (CR) bacteria. The relative importance of and CR contacts unknown. We applied a statistical model estimate the total rate immunizing infections prior wide-scale vaccinations Finland UK. average rates these were 0.7 1.2 per year child UK, respectively. Using rough 0.1 acquisitions UK carriage rates, proportion among all was order 10%, suggesting that bacteria have major role. In general, varying frequency may explain some differences pre-vaccination incidence age-distribution different countries.
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