Levels of antibodies specific to tetanus toxoid, Haemophilus influenzae type b, and pneumococcal capsular polysaccharide in healthy children and adults.
作者： Uwe Schauer , Frank Stemberg , Christian H. L. Rieger , Wolfgang Büttner , Michael Borte
DOI: 10.1128/CDLI.10.2.202-207.2003
关键词:
摘要: Antibody levels specific for capsular polysaccharides of Streptococcus pneumoniae and Haemophilus influenzae type b (Hib) tetanus toxoid were measured in serum samples 386 age-stratified subjects. The study group consists healthy adult blood donors hospitalized children undergoing elective surgery, excluding individuals with a history infection. In children, anti-tetanus antibody displayed two peaks 1.20 IU/ml (20.4 mg/liter) 1.65 (28.1 related to the schedule routine childhood immunization first year at 8 years age. Eighty percent antibodies are immunoglobulin G1 (IgG1) isotype. For pneumococcal polysaccharide (PCP), represent acquisition natural immunity. initial concentration 9.2 mg/liter was low infancy (0.5 1 age) remained until 3 4 age (14.6 mg/liter). During this period PCP almost 100% IgG2 subclass. Thereafter, IgG anti-PCP titers increased steadily (59.5 data intended provide reference ranges aid interpretation determinations clinical setting.
sci-hub.se 参考文章(33)
H M Chapel, Consensus on diagnosis and management of primary antibody deficiencies. Consensus Panel for the Diagnosis and Management of Primary Antibody Deficiencies. BMJ. ,vol. 308, pp. 581- 585 ,(1994) , 10.1136/BMJ.308.6928.581
E. R. Moxon, J. S. Kroll, The Role of Bacterial Polysaccharide Capsules as Virulence Factors Current Topics in Microbiology and Immunology. ,vol. 150, pp. 65- 85 ,(1990) , 10.1007/978-3-642-74694-9_4
D AMBROSINO, D UMETSU, G SIBER, G HOWIE, T GOULARTE, R MICHAELS, P MARTIN, P SCHUR, J NOYES, G SCHIFFMAN, Selective defect in the antibody response to Haemophilus influenzae type b in children with recurrent infections and normal serum IgG subclass levels The Journal of Allergy and Clinical Immunology. ,vol. 81, pp. 1175- 1179 ,(1988) , 10.1016/0091-6749(88)90887-1
H. L. Spiegelberg, A. H. Lucas, R. L. Rubin, Fu-Lin Tang, E. M. Tan, IgG subclasses of anti-tetanus toxoid antibodies in adult and newborn normal subjects and in patients with systemic lupus erythematosus, Sjogren's syndrome, and drug-induced autoimmunity. Journal of Immunology. ,vol. 137, pp. 2522- 2527 ,(1986)
M. A. HAZLEWOOD, D. S. KUMARARATNE, A. D. B. WEBSTER, M. GOODALL, P. BIRD, M. DAHA, An association between homozygous C3 deficiency and low levels of anti-pneumococcal capsular polysaccharide antibodies. Clinical and Experimental Immunology. ,vol. 87, pp. 404- 409 ,(2008) , 10.1111/J.1365-2249.1992.TB03010.X
T. LEINO, K. AURANEN, P. H. MÄKELÄ, H. KÄYHTY, M. RAMSAY, M. SLACK, A. K. TAKALA, Haemophilus influenzae type b and cross-reactive antigens in natural Hib infection dynamics; modelling in two populations Epidemiology and Infection. ,vol. 129, pp. 73- 83 ,(2002) , 10.1017/S0950268802007173
O. Simonsen, M.W. Bentzon‡, I. Heron, ELISA for the routine determination of antitoxic immunity to tetanus. Journal of Biological Standardization. ,vol. 14, pp. 231- 239 ,(1986) , 10.1016/0092-1157(86)90008-9
Artur Galazka, Jacobus Keja, Diphtheria: incidence trends and age-wise changes of immunity. Scandinavian Journal of Infectious Diseases. ,vol. 20, pp. 355- 356 ,(1988) , 10.3109/00365548809032467
C. Cunningham-Rundles, Clinical and immunologic analyses of 103 patients with common variable immunodeficiency. Journal of Clinical Immunology. ,vol. 9, pp. 22- 33 ,(1989) , 10.1007/BF00917124
Richard A. Insel, Porter W. Anderson, Response to oligosaccharide-protein conjugate vaccine against Hemophilus influenzae b in two patients with IgG2 deficiency unresponsive to capsular polysaccharide vaccine. The New England Journal of Medicine. ,vol. 315, pp. 499- 503 ,(1986) , 10.1056/NEJM198608213150807