Flexibility and Disorder in Gene Regulation: LacI/GalR and Hox Proteins

摘要: To modulate transcription, a variety of input signals must be sensed by genetic regulatory proteins. In these proteins, flexibility and disorder are emerging as common themes. Prokaryotic regulators generally have short, flexible segments, whereas eukaryotic extended regions that lack predicted secondary structure (intrinsic disorder). Two examples illustrate the impact on gene regulation: prokaryotic LacI/GalR family, with detailed information from studies LacI, family Hox specific insights investigations Ultrabithorax (Ubx). The widespread importance structural in proteins may derive need for signal response and, particularly eukaryotes, protein partner selection.