Treatment of intrauterine growth restriction with maternal growth hormone supplementation in sheep
作者： Hendrina A. de Boo , Simona C. Eremia , Frank H. Bloomfield , Mark H. Oliver , Jane E. Harding
DOI: 10.1016/J.AJOG.2008.04.035
关键词:
摘要: Objective This study was undertaken to investigate whether maternal growth hormone supplementation in pregnant sheep could reverse intrauterine restriction (IUGR) induced by placental embolization. Study Design Animals were randomized into control, + saline or (twice daily injections of 0.1 mg/kg hormone) groups. Intrauterine twice embolization between 93 and 99 days' gestation, treatment from 100-128 gestation (term = 147 gestation). Results Embolization reduced fetal rate body weight but increased brain-to-liver ratio. Growth significantly rates fat deposition, improved length, not liver weight. produced hydranencephalic brain lesions some fetuses. Conclusion Maternal partially reversed caused insufficiency. However, the possible connection injury requires further investigation
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sci-hub.se 参考文章(48)
B. A. Costine, E. K. Inskeep, M. E. Wilson, Growth hormone at breeding modifies conceptus development and postnatal growth in sheep. Journal of Animal Science. ,vol. 83, pp. 810- 815 ,(2005) , 10.2527/2005.834810X
Breier Bh, Blum Wf, Radioimmunoassays for IGFs and IGFBPs. Growth regulation. ,vol. 4, pp. 11- 19 ,(1994)
F. Lok, J. A. Owens, L. Mundy, J. S. Robinson, P. C. Owens, Insulin-like growth factor I promotes growth selectively in fetal sheep in late gestation American Journal of Physiology-regulatory Integrative and Comparative Physiology. ,vol. 270, ,(1996) , 10.1152/AJPREGU.1996.270.5.R1148
Richard N. Heitmann, Dianne J. Dawes, Scott C. Sensenig, Hepatic ketogenesis and peripheral ketone body utilization in the ruminant. Journal of Nutrition. ,vol. 117, pp. 1174- 1180 ,(1987) , 10.1093/JN/117.6.1174
Abigail L. Fowden, R. S. Comline, THE EFFECTS OF PANCREATECTOMY ON THE SHEEP FETUSIN UTERO Quarterly Journal of Experimental Physiology. ,vol. 69, pp. 319- 330 ,(1984) , 10.1113/EXPPHYSIOL.1984.SP002808
Frank H. Bloomfield, Pierre L. van Zijl, Michael K. Bauer, Jane E. Harding, A chronic low dose infusion of insulin-like growth factor I alters placental function but does not affect fetal growth Reproduction, Fertility and Development. ,vol. 14, pp. 393- 400 ,(2002) , 10.1071/RD02022
Véronique Mirlesse, Francis Frankenne, Eliane Alsat, Micheline Poncelet, Georges Hennen, Danièle Evain-Brion, Placental growth hormone levels in normal pregnancy and in pregnancies with intrauterine growth retardation. Pediatric Research. ,vol. 34, pp. 439- 442 ,(1993) , 10.1203/00006450-199310000-00011
C.M.C. Jenkinson, S.H. Min, D.D.S. Mackenzie, S.N. McCutcheon, B.H. Breier, P.D. Gluckman, Placental development and fetal growth in growth hormone-treated ewes. Growth Hormone & Igf Research. ,vol. 9, pp. 11- 17 ,(1999) , 10.1054/GHIR.1998.0065
MH Oliver, JE Harding, BH Breier, PD Gluckman, Fetal insulin-like growth factor (IGF)-I and IGF-II are regulated differently by glucose or insulin in the sheep fetus. Reproduction, Fertility and Development. ,vol. 8, pp. 167- 172 ,(1996) , 10.1071/RD9960167
Valerie Charlton, Michael Johengen, Effects of Intrauterine Nutritional Supplementation on Fetal Growth Retardation Neonatology. ,vol. 48, pp. 125- 142 ,(1985) , 10.1159/000242164