Decreasing Tumor Growth and Angiogenesis by Inhibition of Coagulation.
作者： Yona Nadir , None
关键词:
摘要: Data regarding the effect of coagulation proteins on enhancing angiogenesis and tumor growth are ample. Thus, inhibition system in an attempt to reduce metastasis seems appealing. However, such molecules as direct oral anticoagulants, warfarin heparins, may impose a bleeding tendency, limiting treatment dose that can be used. The heparanase protein, cofactor for tissue factor (TF) activity, enhances activation addition has several nonhemostatic effects increasing growth. currently investigated field cancer heparin mimetics inhibitors derived from TF pathway inhibitor 2. Both groups pose low tendency. Hence, interfering activity promising target development antitumor drugs.
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