Controlling pH by electronic ion pumps to fight fibrosis

摘要: Abstract Fibrosis and scar formation is a medical condition observed under various circumstances, ranging from skin wound healing to cardiac deterioration after myocardial infarction. Among other complex interdependent phases during healing, fibrosis associated with an increased fibroblast myofibroblast transition. A common hypothesis that decreasing the pH of non-healing, alkaline wounds range 6.0 6.5 increases rates. new material-based strategy change by use electronic ion pumps here proposed. In contrast passive acidic dressings limited non-controlled delivery kinetics, unique pump design operation enables continuous regulation H+ over prolonged durations. in vitro model, differentiation attenuated lowering physiological regime 6.62 ± 0.06. Compared differentiated myofibroblasts media at 7.4, gene protein expression relevant markers α-smooth muscle actin collagen 1 significantly reduced. conclusion, can be steered controlling cellular microenvironment technology as bioelectronic drug devices. This opens up therapeutic avenues induce scar-free healing.