Localisation of RA175 (Cadm1), a cell adhesion molecule of the immunoglobulin superfamily, in the mouse testis, and analysis of male infertility in the RA175-deficient mouse
作者： M. Maekawa , C. Ito , Y. Toyama , F. Suzuki-Toyota , E. Fujita
DOI: 10.1111/J.1439-0272.2010.01049.X
关键词:
摘要: Summary RA175, a member of the immunoglobulin superfamily, plays an important role in cell adhesion, and RA175 gene-deficient mice (RA175−/−) show oligoastheno-teratozoospermia. To understand function RA175, location testis morphological features its spermatogenic cells RA175−/− were investigated. Immunohistochemical studies revealed that immunoreactivity was observed on surface at specific stages. A strong reaction detected from type spermatogonia to pachytene spermatocytes stage IV step 6 16 spermatids during spermatogenesis. From VI 4 spermatids, not by enzyme-labelled antibody method faintly indirect immunofluorescence method. Abnormal vacuoles seminiferous epithelium, showing exfoliation germ cells, ultrastructural abnormality elongate testes. Other members superfamily such as basigin, nectin-2 nectin-3, which have spermatogenesis, immunohistochemically testis. These observations indicate unique expression pattern provide clues regarding mechanism male infertility
sci-hub.se 参考文章(32)
Tomohiko Wakayama, Yoshimichi Sai, Akihiko Ito, Yukio Kato, Miho Kurobo, Yoshinori Murakami, Emi Nakashima, Akira Tsuji, Yukihiko Kitamura, Shoichi Iseki, Heterophilic Binding of the Adhesion Molecules Poliovirus Receptor and Immunoglobulin Superfamily 4A in the Interaction Between Mouse Spermatogenic and Sertoli Cells1 Biology of Reproduction. ,vol. 76, pp. 1081- 1090 ,(2007) , 10.1095/BIOLREPROD.106.058974
Dirk G de Rooij, J Anton Grootegoed, Spermatogonial Stem Cells Current Opinion in Cell Biology. ,vol. 10, pp. 694- 701 ,(1998) , 10.1016/S0955-0674(98)80109-9
Tatsushi Shingai, Wataru Ikeda, Shigeki Kakunaga, Koji Morimoto, Kyoji Takekuni, Shinsuke Itoh, Keiko Satoh, Masakazu Takeuchi, Toshio Imai, Morito Monden, Yoshimi Takai, Implications of nectin-like molecule-2/IGSF4/RA175/SgIGSF/TSLC1/SynCAM1 in cell-cell adhesion and transmembrane protein localization in epithelial cells. Journal of Biological Chemistry. ,vol. 278, pp. 35421- 35427 ,(2003) , 10.1074/JBC.M305387200
Hiroki Gomyo, Yasuhito Arai, Akira Tanigami, Yoshinori Murakami, Masahira Hattori, Fumie Hosoda, Kyoko Arai, Yukiko Aikawa, Hitoshi Tsuda, Setsuo Hirohashi, Shuichi Asakawa, Nobuyoshi Shimizu, Eiichi Soeda, Yoshiyuki Sakaki, Misao Ohki, A 2-Mb sequence-ready contig map and a novel immunoglobulin superfamily gene IGSF4 in the LOH region of chromosome 11q23.2. Genomics. ,vol. 62, pp. 139- 146 ,(1999) , 10.1006/GENO.1999.6001
Kumi Ozaki-Kuroda, Hiroyuki Nakanishi, Hiroshi Ohta, Hiromitsu Tanaka, Hidetake Kurihara, Steffen Mueller, Kenji Irie, Wataru Ikeda, Tatsuo Sakai, Eckard Wimmer, Yoshitake Nishimune, Yoshimi Takai, Nectin couples cell-cell adhesion and the actin scaffold at heterotypic testicular junctions. Current Biology. ,vol. 12, pp. 1145- 1150 ,(2002) , 10.1016/S0960-9822(02)00922-3
Daisuke Yamada, Midori Yoshida, Yuko N. Williams, Takeshi Fukami, Shinji Kikuchi, Mari Masuda, Tomoko Maruyama, Tsutomu Ohta, Dai Nakae, Akihiko Maekawa, Tadaichi Kitamura, Yoshinori Murakami, Disruption of Spermatogenic Cell Adhesion and Male Infertility in Mice Lacking TSLC1/IGSF4, an Immunoglobulin Superfamily Cell Adhesion Molecule Molecular and Cellular Biology. ,vol. 26, pp. 3610- 3624 ,(2006) , 10.1128/MCB.26.9.3610-3624.2006
Eriko Fujita, Yoriko Kouroku, Satomi Ozeki, Yuko Tanabe, Yoshiro Toyama, Mamiko Maekawa, Naosuke Kojima, Haruki Senoo, Kiyotaka Toshimori, Takashi Momoi, Oligo-Astheno-Teratozoospermia in Mice Lacking RA175/TSLC1/SynCAM/IGSF4A, a Cell Adhesion Molecule in the Immunoglobulin Superfamily Molecular and Cellular Biology. ,vol. 26, pp. 718- 726 ,(2006) , 10.1128/MCB.26.2.718-726.2006
Abraham L. Kierszenbaum, Laura L. Tres, Eugene Rivkin, Ningling Kang-Decker, Jan M. A. van Deursen, The Acroplaxome Is the Docking Site of Golgi-Derived Myosin Va/Rab27a/b- Containing Proacrosomal Vesicles in Wild-Type and Hrb Mutant Mouse Spermatids Biology of Reproduction. ,vol. 70, pp. 1400- 1410 ,(2004) , 10.1095/BIOLREPROD.103.025346
Yoshimi Takai, Kenji Irie, Kazuya Shimizu, Toshiaki Sakisaka, Wataru Ikeda, Nectins and nectin-like molecules: roles in cell adhesion, migration, and polarization. Cancer Science. ,vol. 94, pp. 655- 667 ,(2003) , 10.1111/J.1349-7006.2003.TB01499.X
Tomohiko Wakayama, Hiroyuki Koami, Hiroyuki Ariga, Daisuke Kobayashi, Yoshimichi Sai, Akira Tsuji, Miyuki Yamamoto, Shoichi Iseki, Expression and Functional Characterization of the Adhesion Molecule Spermatogenic Immunoglobulin Superfamily in the Mouse Testis Biology of Reproduction. ,vol. 68, pp. 1755- 1763 ,(2003) , 10.1095/BIOLREPROD.102.012344