Increased maternal TSH and decreased maternal FT4 are associated with a higher operative delivery rate in low-risk pregnancies: A prospective cohort study

作者: L. Monen , VJ Pop , TH Hasaart , H. Wijnen , SG Oei

DOI: 10.1186/S12884-015-0702-1

关键词:

摘要: The increasing number of operative deliveries is a topic major concern in modern obstetrics. Maternal thyroid function known influence on many obstetric parameters. Our objective was to investigate possible relation between maternal function, and deliveries. Secondary aim explore whether related specific reasons for In this prospective cohort study, low-risk Caucasian women, pregnant single cephalic fetus were included. Women with auto-immune disease, pre-labour Caesarean section, induction labour, breech presentation or preterm delivery excluded. all trimesters pregnancy the assessed. Differences mean TSH FT4 assessed using t-test. Mean levels determined by one way ANOVA. Repeated measurement analyses performed (ANOVA), adjusting BMI, partiy, age gestational at delivery. total 872 women included, which 699 (80.2 %) had spontaneous At 36 weeks gestation who an significantly higher (1.63mIU/L versus 1.46mIU/L, p = 0.025) lower (12.9pmol/L 13.3pmol/L, p = 0.007)) compared (p = 0.026) (p = 0.030) throughout due failure progress second stage other reasons. Increased decreased seem be associated more vaginal sections. After several confounders association remained possibly explained less efficient uterine action.

参考文章(35)
S K Mishra, V Raviprakash, S C Parija, Hypothyroid state reduces calcium channel function in 18-day pregnant rat uterus. Indian Journal of Experimental Biology. ,vol. 44, pp. 19- 27 ,(2006)
Victor Pop, Maarten Broeren, Wilmar Wiersinga, The Attitude Toward Hypothyroidism During Early Gestation: Time for a Change of Mind? Thyroid. ,vol. 24, pp. 1541- 1546 ,(2014) , 10.1089/THY.2014.0007
Sara Kenyon, Hironobu Tokumasu, Therese Dowswell, Debbie Pledge, Rintaro Mori, High Dose Versus Low Dose Oxytocin for Augmentation of Delayed Labour Cochrane Database of Systematic Reviews. ,(2013) , 10.1002/14651858.CD007201.PUB3
L. Monen, S.M. Kuppens, T.H. Hasaart, H. Wijnen, V.J. Pop, Maternal thyrotrophin in euthyroid women is related to meconium stained amniotic fluid in women who deliver at or over 41 weeks of gestation Early Human Development. ,vol. 90, pp. 329- 332 ,(2014) , 10.1016/J.EARLHUMDEV.2014.04.002
J Zhang, L Bricker, S Wray, S Quenby, Poor uterine contractility in obese women British Journal of Obstetrics and Gynaecology. ,vol. 114, pp. 343- 348 ,(2007) , 10.1111/J.1471-0528.2006.01233.X
Lara J. Burrows, Leslie A. Meyn, Anne M. Weber, Maternal Morbidity Associated With Vaginal Versus Cesarean Delivery Obstetrics & Gynecology. ,vol. 103, pp. 907- 912 ,(2004) , 10.1097/01.AOG.0000124568.71597.CE
Catalin S. Buhimschi, Irina A. Buhimschi, Andrew M. Malinow, Carl P. Weiner, Uterine contractility in women whose fetus is delivered in the occipitoposterior position American Journal of Obstetrics and Gynecology. ,vol. 188, pp. 734- 739 ,(2003) , 10.1067/MOB.2003.149
P. J. D. Owen, C. Rajiv, D. Vinereanu, T. Mathew, A. G. Fraser, J. H. Lazarus, Subclinical hypothyroidism, arterial stiffness, and myocardial reserve. The Journal of Clinical Endocrinology and Metabolism. ,vol. 91, pp. 2126- 2132 ,(2006) , 10.1210/JC.2005-2108
Christophe Vayssière, Gael Beucher, Olivier Dupuis, Olivia Feraud, Caroline Simon-Toulza, Loïc Sentilhes, Emmanuelle Meunier, Olivier Parant, Thomas Schmitz, Didier Riethmuller, Olivier Baud, Fabienne Galley-Raulin, Pierre Diemunsch, Fabrice Pierre, Jean-Patrick Schaal, Alain Fournié, Jean François Oury, Instrumental delivery: clinical practice guidelines from the French College of Gynaecologists and Obstetricians European Journal of Obstetrics & Gynecology and Reproductive Biology. ,vol. 159, pp. 43- 48 ,(2011) , 10.1016/J.EJOGRB.2011.06.043
KAIE OJAMAA, JOHN D. KLEMPERER, IRWIN KLEIN, Acute Effects of Thyroid Hormone on Vascular Smooth Muscle Thyroid. ,vol. 6, pp. 505- 512 ,(1996) , 10.1089/THY.1996.6.505