The Attitude Toward Hypothyroidism During Early Gestation: Time for a Change of Mind?
作者： Victor Pop , Maarten Broeren , Wilmar Wiersinga
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摘要: Background: The approach not to screen thyroid function of all pregnant women is mainly based on conflicting evidence whether treatment with mild hypothyroidism beneficial. However, there consensus that overt (OH) and those a thyrotropin (TSH) >10 mIU/L should be treated immediately, but data these conditions are scarce. We assessed the prevalence OH TSH during first trimester pregnancy. Methods: Thyroid was at 10–12 weeks gestation in 4199 Dutch Caucasian healthy from three studies conducted 2002, 2005, 2013 same iodine sufficient area southeast Netherlands. defined specific cutoffs (2.5th–97.5th percentile) for free thyroxine (fT4) peroxidase antibody (TPO-Ab) negative each study determine mIU/L. extrapolated figures population...
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