Neonatal thyroid screening results are related to gestational maternal thyroid function.
作者： S.M.I. Kuppens , L. Kooistra , H.A. Wijnen , H.L. Vader , T.H.M. Hasaart
DOI: 10.1111/J.1365-2265.2011.04083.X
关键词:
摘要: Summary Objective To study the relationship between maternal thyroid function at each pregnancy trimester and neonatal screening results. Background Overt dysfunction during gestation is associated with poor function. However, research on suboptimal (assessed three trimesters) outcome scarce. Design/Patients Prospective follow-up trimesters of in 886 Dutch Caucasian healthy pregnant women followed from 12-week until term delivery (>37 weeks) their neonates. Measurements The relation data Congenital Hypothyroidism (CH) determinants [TSH, FT4 peroxidase (TPO)-Ab] assessed 12-, 24- 36-week gestation. Results Boys have lower TT4 levels mothers higher TSH gestation. Higher (>97·5th percentile, as defined 810 without TPO-Ab 12 weeks) one or more times (O.R: 2·26, 95% CI: 1·20–4·29) gestational age 1·22, 1·05–1·41) are independently related to levels. Conclusions Maternal screening. finding both boys carrying worthy further investigation, observations may be meaningfully related.
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