Prognostic and Predictive Significance of Stromal Fibroblasts and Macrophages in Colon Cancer

摘要: Colon cancer development and malignant progression are driven by genetic epigenetic alterations in tumor cells factors from the microenvironment. Cancer become reliant on activity of specific oncogenes prosurvival proliferative signals they receive abnormal environment create reside in. Accordingly, response to anticancer therapy is determined changes that intrinsic present Recent advances understanding involvement microenvironment therapeutic optimizing application prognostic predictive colon cancer. Moreover, new targets amenable intervention have been identified. Because stromal with rare exceptions genetically stable, has emerged as a preferred target for drugs. In this review, we discuss role fibroblasts macrophages patients therapy.