Pituitary-adrenal activity and depletion of brain catecholamines after α-methyl-p-tyrosine administration
作者： J. Kaplanski , W. Dorst , P.G. Smelik
DOI: 10.1016/0014-2999(72)90154-9
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摘要: Abstract I.p. injection of 250 mg/kg α-methyl-p-tyrosine (α-MT), into male rats, increased adrenocortical activity. In contrast, repeated administration 50 α-MT, did not activate the pituitary-adrenal system. However, both treatments induced a significant fall in brain catecholamine (CA) content. This datum questions causal relationship between CA depletion and stimulation ACTH secretion.
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sci-hub.se 参考文章(12)
U. Scapagnini, G.R. Van Loon, G.P. Moberg, W.F. Ganong, Effect of α-methyl-p-tyrosine on the circadian variation of plasma corticosterone in rats European Journal of Pharmacology. ,vol. 11, pp. 266- 268 ,(1970) , 10.1016/0014-2999(70)90057-9
M.Kent Shellenberger, J.H. Gordon, A rapid, simplified procedure for simultaneous assay of norepinephrine, dopamine, and 5-hydroxytryptamine from discrete brain areas Analytical Biochemistry. ,vol. 39, pp. 356- 372 ,(1971) , 10.1016/0003-2697(71)90426-X
G. R. VAN LOON, U. SCAPAGNINI, G. P. MOBERG, W. F. GANONG, Evidence for central adrenergic neural inhibition of ACTH secretion in the rat. Endocrinology. ,vol. 89, pp. 1464- 1469 ,(1971) , 10.1210/ENDO-89-6-1464
E.V. Naumenko, Hypothalamic chemoreactive structures and the regulation of pituitary-adrenal function. Effects of local injections of norepinephrine, carbachol and serotonin into the brain of guinea pigs with intact brains and after mesencephalic transection. Brain Research. ,vol. 11, pp. 1- 10 ,(1968) , 10.1016/0006-8993(68)90069-3
G. A. Hedge, P. G. Smelik, Corticotropin release: inhibition by intrahypothalamic implantation of atropine. Science. ,vol. 159, pp. 891- 892 ,(1968) , 10.1126/SCIENCE.159.3817.891
]. van der Vies, R. F. M. Bakker, D. de Wied, Correlated studies on plasma free corticosterone and on adrenal steroid formation rate in vitro. European Journal of Endocrinology. ,vol. 34, pp. 513- 523 ,(1960) , 10.1530/ACTA.0.XXXIV0513
J. K. Bert, K. E. Moore, P. F. Wright, Toxicologic studies with alpha-methyltyrosine, an inhibitor of tyrosine hydroxylase. Journal of Pharmacology and Experimental Therapeutics. ,vol. 155, pp. 506- 515 ,(1967)
S. Spector, A. Sjoerdsma, S. Udenfriend, BLOCKADE OF ENDOGENOUS NOREPINEPHRINE SYNTHESIS BY ALPHA-METHYL-TYROSINE, AN INHIBITOR OF TYROSINE HYDROXYLASE. Journal of Pharmacology and Experimental Therapeutics. ,vol. 147, pp. 86- 95 ,(1965)
H. K. Borys, R. H. Rech, K. E. Moore, ALTERATIONS IN BEHAVIOR AND BRAIN CATECHOLAMINE LEVELS IN RATS TREATED WITH α-METHYLTYROSINE Journal of Pharmacology and Experimental Therapeutics. ,vol. 153, pp. 412- 419 ,(1966)
Thornburg Je, Moore Ke, Stress-related effects of various inhibitors of catecholamine synthesis in the mouse. Archives internationales de pharmacodynamie et de thérapie. ,vol. 194, pp. 158- 167 ,(1971)