Diversity and Genetic Basis for Carbapenem Resistance in a Coastal Marine Environment.

摘要: Resistance to the "last-resort" antibiotics, such as carbapenems, has led very few antibiotics being left treat infections by multidrug-resistant bacteria. Spread of carbapenem resistance (CR) been well characterized for clinical environment. However, there is a lack information about its environmental distribution. Our study reveals that CR present in wide range Gram-negative bacteria coastal seawater environment, including four phyla, eight classes, and 30 genera. These were likely introduced into via stormwater flows. Some isolates found here, Acinetobacter junii, johnsonii, Brevundimonas vesicularis, Enterococcus durans, Pseudomonas monteilii, fulva, Stenotrophomonas maltophilia, are further relevant human health. We also describe novel metallo-β-lactamase (MBL) marine Rheinheimera with CR, which horizontally transferred Citrobacter freundii or Enterobacter cloacae In contrast, another MBL New Delhi type was acquired Variovorax from Escherichia coli, Klebsiella pneumoniae, baumannii utilizing plasmid. findings add growing body evidence aquatic environment both reservoir vector genes.IMPORTANCE against family often based on production carbapenemases, this frequently observed samples. dissemination less explored. shows commonly bacterial taxa can involve exchange metallo-β-lactamases typical potential pathogens vice versa. The outcomes contribute better understanding how act reservoirs vectors outside setting.