A New Paradigm for Vascular Endothelial Cell Growth Factor Receptor Signaling in Adult Endothelium

摘要: The primary role of the endometrium is cyclical generation a receptive uterine lining for successful implantation fertilized ovum, process that dependent on growth new blood vessels. Outside female reproductive tract, majority adult vasculature quiescent and angiogenesis occurs only as part body’s repair processes or in diseases including diabetic retinopathy, rheumatoid arthritis, atherosclerosis, cancer. cellular localization several angiogenic factors has been described endometrium, although their precise biological roles normal cycling endometrial pathologies, such endometriosis cancer, yet to be established. However, it clear vascular endothelial cell factor (VEGF) central pathophysiological occurring endometrium. VEGF elicits its responses via two high-affinity tyrosine kinase receptors, namely VEGFR-1 VEGFR-2. Until recently, was presumed effects induced by were mediated VEGFR-2, whereas acted decoy. results from our laboratory others have identified an important mediator signaling during adult. We shown activation leads nitric oxide, which acts cue negative regulation VEGFR-2-dependent proliferation promotes reorganization into three-dimensional vessel networks.