Gamma and pulse radiolysis investigation of the reaction of desferrioxamine with superoxide anions

摘要: SummaryThe kinetic scheme of the reaction desferrioxamine (DFO) with O2 was studied using pulse and γ-radiolysis. The rate constant k(O2 + DFO) is equal to 1·3 ± 0·1 × 106 dm3 mol−1 s−1 at pH 7·4. Studying competition between DFO ferricytochrome-c for generated by γ-radiolysis, we observed that nitroxide free radical resulting from product(s) decay this act inversely towards cytochrome-c-Fe3+/cytochrome-c-Fe2+ redox couple. This explains discrepancy our value one measured previously detection O2. reported results show acts as a powerful scavenger, products can initiate oxidative and/or reductive reactions should be taken into account in interpreting effects vitro vivo.