Possible involvement of μ-opioid receptors in effect of lithium on inhibitory avoidance response in mice

摘要: In the present study, effects of intracerebroventricular (i.c.v.) injections μ-opioid receptor agonist and antagonist on lithium state-dependency were investigated. For memory assessment, a one-trial step-down inhibitory avoidance task was used in adult male NMRI mice. Intraperitoneal (i.p.) administration (10 mg/kg) after training impaired when retrieval tested 24 h later. The impairment reversed by pretest same dose lithium, suggesting induced lithium. addition, i.c.v. both (2 4 μg/mouse, i.c.v.) morphine (3 6 before test post-training mg/kg, i.p.). On other hand, naloxone (1 2 which had no alone response, prevented improving retrieval. results s...