Topical treatment with hexadecylphosphocholine (Miltex®) efficiently reduces parasite burden in experimental cutaneous leishmaniasis

摘要: Ether-lipids and alkylphosphocholines have been found to anti-leishmanial activity. Oral treatment with hexadecylphosphocholine (HePC) efficiently reduces parasite burden in murine visceral leishmaniasis. Drugs for the of cutaneous leishmaniasis are most commonly administered parenterally, whereas efficient drugs topical not current use. Here we investigate efficacy HePC mice infected Leishmania mexicana or L. major, causative agents New Old World, respectively. BALB/c, CBA/J C57BL/6 inbred do control infection because they mount an Th1-type anti-parasitic lymphocyte response. In contrast, resistant developing only transient lesions that heal spontaneously owing Th1 were subcutaneously amastigotes, causing nodular after 5 months. Topical (Miltex) was highly effective reducing healed established lesions. The did induce a response mexicana-infected susceptible relapsed. 2 x 10(6) major promastigotes at tail base, developed weeks. Miltex reduced load their much faster than untreated controls. clinical application may be humans, similarly mice, general relapse healing. Clinical trials should straightforward considering is approved drug breast cancer metastases.