In vitro antiviral and antibacterial activity of commercial intravenous immunoglobulin preparations – a potential role for adjuvant intravenous immunoglobulin therapy in infectious diseases*

摘要: The identification of specific antimicrobial activity intravenous immunoglobulin (IVIG) preparations against particular microbial pathogens can assist in determining their therapeutic potential for infectious diseases. We analysed five different commercial IVIG the presence antibodies directed a large panel viral, bacterial, fungal and parasitic pathogens. All batches contained high herpesviruses types 1, 2, 6 7, as well varicella zoster virus, Epstein-Barr virus (EBV), measles, mumps, rubella parvovirus B19. Some also had significant adenovirus Saint Louis encephalitis virus. IVIGs held several bacterial pathogens, including Mycoplasma pneumonia, Chlamydia Helicobacter pylori tetanus. No was found various Our findings may provide further support use prevention treatment infections caused by viral