Moderating risk of Alzheimer's disease through the use of anxiolytic agents
作者： Shanna L. Burke , Janice O'Driscoll , Amary Alcide , Tan Li
DOI: 10.1002/GPS.4614
关键词:
摘要: Objectives Anxiety diagnoses occur in 17.1% people age 65 years and older. Individuals with anxiety may be at a higher risk of the development probable Alzheimer's disease (AD). Previous literature has suggested that anxiolytic medications exacerbate AD development. This study explored medication as potential moderator older adults. Methods A secondary data analysis National Coordinating Center Uniform Data Set was undertaken, analyzing observations from 12,083 participants normal cognition first visit. Survival utilized to examine if use by those and/or APOE ɛ4 moderates hazard MCI development. Results The (HR = 3.50, [2.77 – 4.44], p < .0001) or (HR = 2.13, [1.85–2.44], statistically significant for anxiety. no longer when specific anxiolytics were used. carriers experienced (HR = 1.92, [1.52–2.41], p < .001) (HR = 1.17, [1.04–1.32], p < .05) effect moderated anxiolytics. Discussion The results this suggest moderate on development, specifically indicating neutralized Copyright © 2016 John Wiley & Sons, Ltd.
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