S-Adenosyl-l-methionine: its role in the treatment of liver disorders

摘要: S-Adenosyl-L-methionine (SAMe) exerts many key functions in the liver, including serving as a precursor for cysteine, 1 of 3 amino acids glutathione--the major physiologic defense mechanism against oxidative stress. SAMe is particularly important opposing toxicity free oxygen radicals generated by various pathogens, alcohol, which cause stress largely induction cytochrome P4502E1 (CYP2E1) and its metabolite acetaldehyde. also acts main methylating agent liver. The methionine, one essential acids, activated SAMe-synthetase (EC 2.5.1.6). Unfortunately, activity this enzyme significantly decreased consequence liver disease. Because utilization, methionine accumulates and, simultaneously, there decrease that acquires status an nutrient therefore must be provided exogenously supernutrient to compensate deficiency. Administration innocuous results beneficial effects tissues, mainly especially mitochondria. This was shown alcohol-fed baboons other experimental models injury clinical trials, some are reviewed articles issue.