Functions of Glutathione in Drug Metabolism
作者： S. Orrenius , D. P. Jones
DOI: 10.1007/978-3-642-67132-6_20
关键词:
摘要: The liver cytochrome P-450 monooxygenase system can be responsible for generation of a variety reactive metabolites, including hydrogen peroxide, aldehydes, and epoxides which, unless inactivated by further metabolism, may produce cytotoxicity. In this study we have examined the role glutathione (GSH) in detoxification such species isolated hepytocytes investigating (1) peroxidase H2O2 decomposition, (2) formaldehyde dehydrogenase HCHO oxidation, (3) GSH bromobenzene metabolism.
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sci-hub.st 参考文章(27)
Hjördis Thor, Peter Moldéus, Sten Orrenius, Metabolic activation and hepatotoxicity. Effect of cysteine, N-acetylcysteine, and methionine on glutathione biosynthesis and bromobenzene toxicity in isolated rat hepatocytes. Archives of Biochemistry and Biophysics. ,vol. 192, pp. 405- 413 ,(1979) , 10.1016/0003-9861(79)90109-7
Irwin M. Arias, William B. Jakoby, Glutathione, metabolism and function Raven Press. ,(1976)
Lasse Uotila, Martti Koivusalo, Formaldehyde Dehydrogenase from Human Liver Journal of Biological Chemistry. ,vol. 249, pp. 7653- 7663 ,(1974) , 10.1016/S0021-9258(19)81287-5
S Orrenius, D P Jones, H Thor, B Andersson, Detoxification reactions in isolated hepatocytes. Role of glutathione peroxidase, catalase, and formaldehyde dehydrogenase in reactions relating to N-demethylation by the cytochrome P-450 system. Journal of Biological Chemistry. ,vol. 253, pp. 6031- 6037 ,(1978) , 10.1016/S0021-9258(17)34575-1
Hjördis Thor, Peter Moldéus, Rolf Hermanson, Johan Högberg, Donald J. Reed, Sten Orrenius, Metabolic activation and hepatotoxicity. Toxicity of bromobenzene in hepatocytes isolated from phenobarbital-and diethylmaleate-treated rats. Archives of Biochemistry and Biophysics. ,vol. 188, pp. 122- 129 ,(1978) , 10.1016/0003-9861(78)90364-8
Lasse Uotila, Martti Koivusalo, Purification and Properties of S-Formylglutathione Hydrolase from Human Liver Journal of Biological Chemistry. ,vol. 249, pp. 7664- 7672 ,(1974) , 10.1016/S0021-9258(19)81288-7
Britton. Chance, The effect of pH upon the equilibria of catalase compounds. Journal of Biological Chemistry. ,vol. 194, pp. 483- 496 ,(1952) , 10.1016/S0021-9258(18)55800-2
Ronald G. Thurman, Heinz Georg Ley, Roland Scholz, Hepatic Microsomal Ethanol Oxidation FEBS Journal. ,vol. 25, pp. 420- 430 ,(1972) , 10.1111/J.1432-1033.1972.TB01711.X
Richard A. Lawrence, Raymond F. Burk, Glutathione peroxidase activity in selenium-deficient rat liver Biochemical and Biophysical Research Communications. ,vol. 71, pp. 952- 958 ,(1976) , 10.1016/0006-291X(76)90747-6
J Goodman, A comparison of rat and human liver formaldehyde dehydrogenase Biochimica et Biophysica Acta. ,vol. 252, pp. 489- 505 ,(1971) , 10.1016/0304-4165(71)90152-8