Nutritional programming of the metabolic syndrome.

摘要: The primary markers of the metabolic syndrome are central obesity, insulin resistance and hypertension. In this review, we consider effect changes in maternal nutrition during critical windows fetal development on an individual's subsequent predisposition to syndrome. origins cardiovascular disease have been investigated a wide range epidemiological animal studies; these investigations highlight adaptations made by nutritionally manipulated fetus that aim maintain energy homeostasis ensure survival. One consequence such developmental plasticity may be long term re-setting cellular homeostasis, most probably via epigenetic modification genes involved number key regulatory pathways. For example, reduced maternal-fetal early gestation midgestation affects adipose tissue adiposity setting increased adipocyte precursor cells. Importantly, clinically relevant nutritional challenges utero only manifest as components if followed period accelerated growth postnatal and/or offspring become obese.