Effects of hypoperfusion in Alzheimer's disease.

摘要: The role of hypoperfusion in Alzheimer's disease (AD) is a vital component to understanding the pathogenesis this disease. Disrupted perfusion not only evident throughout manifestation, it also demonstrated during pre-clinical phase AD (i.e., mild cognitive impairment) as well cognitively healthy persons at high-risk for developing due family history or genetic factors. Studies have used variety imaging modalities (e.g., SPECT, MRI, PET) investigate AD, but with its recent technological advancements and non-invasive use blood water an endogenous tracer, arterial spin labeling (ASL) MRI has become technique growing popularity. Through numerous ASL studies, now known that associated both global regional cerebral there considerable overlap between regions implicated state (consistently reported precuneus/posterior cingulate lateral parietal cortex) those risk. Debate exists whether decreased flow cause consequence Nonetheless, structural functional changes brain offers promising putative biomarker could potentially identify be explore treatments prevent, least slow, progression Finally, given vascular phenomenon, we provide insights from lesion model stroke) illustrate influence disrupted on structure function and, ultimately, cognition AD.