Severity of Systemic Inflammatory Response Syndrome Affects the Blood Levels of Circulating Inflammatory-Relevant MicroRNAs.

摘要: The systemic inflammatory response syndrome (SIRS) is a potentially lethal triggered by diverse forms of tissue injury and infection. When inflammation infection the term sepsis used. Understanding how mediated regulated enormous medical importance. We previously demonstrated that circulating inflammatory-relevant micro-RNAs (CIR-miRNAs) are candidate biomarkers for differentiating from SIRS. Here we set out to determine CIR-miRNA levels reflect SIRS severity whether they derive activated immune cells. Clinical disease scores markers red blood cell (RBC) damage or activation were correlated with in patients sepsis. release CIR-miRNAs modulated during was assessed cultures. show non-infective SIRS, but not reflected miR-378a-3p, miR-30a-5p, miR-30d-5p, miR-192-5p. These positively correlate redox biomarker, peroxiredoxin-1 (Prdx-1), which has been shown be released cells inflammation. Furthermore, vitro produce SIRS-associated Our study furthers understanding origin, role trafficking as potential regulators