Regulation of Tumor Metastasis by Myeloid-Derived Suppressor Cells
作者： Thomas Condamine , Indu Ramachandran , Je-In Youn , Dmitry I. Gabrilovich
DOI: 10.1146/ANNUREV-MED-051013-052304
关键词:
摘要: Accumulation of pathologically activated immature myeloid cells with potent immune-suppressive activity is one the major immunological hallmarks cancer. In recent years, it became clear that in addition to their activity, myeloid-derived suppressor (MDSCs) influence tumor progression a variety ways. They are directly implicated promotion metastases by participating formation premetastatic niches, promoting angiogenesis and cell invasion. this review, we discuss data describing various roles MDSCs metastases.
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