Risk of Second Primary Malignancies among Patients with Early Gastric Cancer Exposed to Recurrent Computed Tomography Scans

摘要: Although computed tomography (CT) scans are very useful for identification or surveillance of malignancy, they also associated with the risk cancer caused by ionizing radiation. We investigated second primary malignancies (SPMs) after frequent abdominopelvic CT in a cohort Korean patients early gastric (EGC). performed study 11,072 who underwent resection EGC at Samsung Medical Center and validated results using data from 7908 National Health Insurance Service cohort. Cox proportional hazards regression model was used to estimate hazard ratios (HRs) intra-abdominal SPM. During 43,766.5 person-years follow-up our center, 322 developed SPMs. Patients receiving >8 had significantly greater developing SPM (HR, 2.73; 95% CI, 1.66–4.50; p < 0.001) than those ≤8 scans. For each additional scan, adjusted HR 1.09 (95% confidence interval (CI), 1.03–1.14). Similar were observed (adjusted HR, 1.14; 1.07–1.22). Significantly elevated still when considering 2-year latency period 2.43; 1.37–4.48) 3-year 2.17; 1.06–4.47). Frequent an SPMs treatment EGC. Thus, physicians need weigh carefully clinical benefits examinations against potential risks radiation exposure.